张洪波
E-mail: hbzhang@ecust.edu.cn
职位: 博士生导师
职称: 教授
个人简介:
张洪波 教授 博士生导师 毕业于华中科技大学，2004年获得英国诺丁汉特伦特大学 博士学位。2004-2006分别在英国女王大学和伦敦大学作博士后研究。2006.10月就职于杏悦2娱乐致力微流体技术在生物医药中的应用研究👩🦽。先后受到国家自然科学基金、上海市对外合作基金、上海市飞利浦合作基金、上海市创新行动计划等项目资助，与英国女王大学、伦敦大学及国内近10家医疗机构开展了广泛的合作👐🏻⛏。中国生物材料协会先进制造分会委员🗼；3D打印专业委员会委员；在3D生物打印技术及器官芯片技术方面发表50余篇SCI论文🤟🏼，十余项专利授权。
联系方法:
梅陇路130号杏悦2娱乐401信箱🔑，上海 200237
Tel: 0086-21-64253538
Email: hbzhang@ecust.edu.cn
研究方向
(1）生物 3D 打印技术
生物 3D 打印构建骨👨🏼🔬、皮肤、气管组织及肿瘤模型🤹🏻；
开发熔融及电纺、挤出式及光固化生物3D打印技术
(2）微流控与器官芯片技术
微纳米颗粒、肿瘤细胞分离及载药缓释微球💂🏽♀️、微泡造影剂制备
模拟体内微环境🧝🏽，构建皮肤🤾🏼♂️、肾器官芯片用于药物筛选🏄🏻；
(3）个性化可穿戴智能型外骨骼护具及智能传感开发
构建柔性欠驱动假肢👨🏻✈️、肩、肘、手可穿戴式外骨骼护具；
姿态捕捉及生理信号结合用于步态🧑🏿🦳🎂、能耗分析及康复效果评估
承担科研项目
承担项目♈️：
（1）上海市科委创新行动计划 新型抗菌水凝胶敷料的研发和临床前评价👨🚀，2019.4-2022.3
（2）上海市科委“联盟计划” 3D打印活体皮肤组织块用于药物筛选研发，2016.7-2018.1
（3）国家自然科学青年基金🧑🏽🎤，微气泡造影剂对癌症的基因治疗的基础研究👮🏻♀️，2008-2010；
（4）上海市科委非政府合作基金🦥，微流体聚焦法制备治疗型微气泡造影剂的研究💂🏿♀️，2010-2012；
（5）上海市飞利浦合作基金，治疗型微气泡造影剂新型制备方法的可行性研究，2007-2009🧑🏼🍳；
企业合作项目：
获得多项企业🤕、医疗机构联合课题资助
获奖成果
(1) 2014年获得杏悦2娱乐育英奖一等奖；
(2) 2013年获得上海市教学成果一等奖⬛️：机械与化工复合型人才多维度工程能力培养的研究与实践👩🏽🍳；
(3) 2013年上海化工区理工教学二等奖
代表性著作
https://doi.org/10.3390/ph15060695
(6) Yilin Yan, Katharine Smith*, Alejandro Macario-Rojas and Hongbo Zhang *, Simulation of the Landing Buffer of a Three-Legged Jumping Robot. Machines 2022,10,299. https:// doi.org/10.3390/machines10050299
(7) Biosensors and Bioelectronics, 180, 15 May 2021, 113148. https://doi.org/10.1016/j.bios.2021.113148
(8) Yingjie Cai, Dasheng Yang, Ruixue Yin*, Yang Gao*, Hongbo Zhang* and Wenjun Zhang, An enzyme-free capacitive glucose sensor based on dual-network glucose-responsive hydrogel and coplanar electrode, The Analyst, 2021,146(1), 213-221.
(9) Zhitao Liu, Hongbo Zhang* and Huanxin Lai*, Fluid flow effects on the degradation kinetics of bioresorbable polymers, Computer Methods in Biomechanics and Biomedical Engineering, 2021, DOI: 10.1080/10255842.2020.1867115.
(10) Tiandi Wang, Jianchao Zheng, Tianzhou Hu, Hongbo Zhang, Kun Fu, Ruixue Yin and Wenjun Zhang. Three-Dimensional Printing of Calcium Carbonate/Hydroxyapatite Scaffolds at Low Temperature for Bone Tissue Engineering. 3D printing and additive manufacturing, 2021, 8(1)🕵️，1-13. DOI: 10.1089/3dp.2020.0140.
(11) Jinling Zhu,Minqi Wang, Hongbo Zhang*,Shengbing Yang*, Ki-Young Song, Ruixue Yin and Wenjun Zhang. Effects of Hydrophilicity, Adhesion Work, and Fluid Flow on Biofilm Formation of PDMS in Microfluidic Systems. ACS Applied Bio Materials, 2020, 3. 10.1021/acsabm.0c00660.
(12) P.W. Xu, F.L. Jiang, H.B. Zhang*, R.X. Yin, L. Cen and W.J. Zhang*. Calcium Carbonate / Gelatin Methacrylate Microspheres for 3D Cell Culture in Bone Tissue Engineering Part C, 2020, 26 (8), 418-432. (IF:2.608)
(13)S.Y. Gai, J.J. Xu, H.B. Zhang*, R.X. Yin and W.J. Zhang*. Effects of Nanofillers on the Hydrolytic Degradation of Polyesters. Tissue engineering part B, March, 5th, 2020, published online. （IF:6.512)
(14) L. Lei, H.B. Zhang*, D. Bergstrom, T. Anthony, K.Y.Song, W.J. Zhang*. Experimental and simulation study of flow patterns in the combined flow focusing and T-junction device. Journal of Micromechanics and Microengineering, 2020, 30, 055001. (IF: 2.15)
(15) H.P. Si, T.L. Xing, Y.L. Ding, H.B. Zhang*, R.X. Yin and W.J. Zhang. 3D Bioprinting of the Sustained Drug Release Wound Dressing with Double-Crosslinked Hyaluronic-Acid-Based Hydrogels. Polymers 2019, 11(10), 1584.（IF:3.363）
(16) Y.H. Jia, H.B. Zhang*, S.B. Yang*, Z.H. Xi, T.T. Tang, R.X. Yin, W.J. Zhang. Electrospun PLGA membrane incorporated with Andrographolide-loaded Mesoporous Silica Nanoparticles for sustained antibacterial wound dressing. Nanomedicine, 2018, 13(22):2881-2899. (IF:5.005
(17) C.H. Ma, H.B. Zhang*, S. M. Yang, R. X. Yin, X. J. Yao, and W. J. Zhang. Comparison of the degradation behavior of PLGA scaffolds in micro-channel, shaking, and static conditions. Biomicrofluidics, 2018, 12, 034106.（IF:2.571）
(18)Y. Shi, T.L. Xing, H.B. Zhang*, R.X. Yin, Sh. M. Yang, J. Wei and W.J. Zhang. Tyrosinase doped bioink for 3D bioprinting of living skin constructs. Biomedical materials, 2018, 13, 035008.（IF:2.897）
(19) Y. Yang, L.Y. Chu, S.B. Yang, H.B. Zhang, L. Qin, O. Guillaume, D. Eglin, R. G. Richards, T.T. Tang. Dual-functional 3D-printed composite scaffold for inhibiting bacterial infection and promoting bone regeneration in infected bone defect models. Acta Biomaterialia, 2018, 79:265-275 46:112-128.（IF:6.319）
(20) S.B. Yang, X.G. Han, Y.H. Jia, H.B. Zhang* and T.T. Tang*. Hydroxypropyltrimethyl Ammonium Chloride Chitosan Functionalized-PLGA Electrospun Fibrous Membranes as Antibacterial Wound Dressing: In Vitro and In Vivo Evaluation. Polymers 2017, 9(12), 697.（IF:3.363）
(21) L. Lei, D. Bergstrom, B. Zhang, H.B. Zhang*, R. Yin, K.Y. Song and W.J. Zhang*. Micro/Nanospheres Generation by Fluid-Fluid Interaction Technology: A Literature Review. Recent Patents on Nanotechnology, 2017, 11, 15-33.（IF: 1.475）
(22) R. Yin, N. Zhang, K. Wang, H. Long, T.L. Xing, J. Nie, H.B. Zhang and W.J. Zhang. Material design and photo-regulated hydrolytic degradation behavior of tissue engineering scaffolds fabricated via 3D fiber deposition. Journal of Materials Chemistry B, 2017, 5, 329-340.（IF:4.543）
(23) Z.M. Du, N.F. Li, Y.J. Hua, Y. Shi, C.Y. Bao, H.B. Zhang, Y. Yang, Q.N. Lin, L.Y. Zhu. Physiological pH-dependent gelation for 3D printing based on the phase separation of gelatin and oxidized dextran. Chemical Communication, 2017, 53(97):13023-13026. (IF:6.29)
(24) H.B. Zhang*, T.L.Xing, Y. Shi, R.X.Yin, S.M.Yang and W.J. Zhang. 3D bioprinting is not only about cell-laden structures. Chinese Journal of Traumatology, 2016, 19:187-192. (MEDLINE)
(25) S. Duan, K. Yang, Z.H. Wang, M.T. Chen, L. Zhang*, H.B. Zhang* and C.Z. Li, Fabrication of Highly Stretchable Conductors Based on 3D Printed Porous Poly(dimethylsiloxane) and Conductive Carbon Nanotubes/Graphene Network, ACS Applied Materials & Interface, 2016, 27;8(3):2187-92.（IF:8.097）
(26) Y. Yang, S.B. Yang, Y. Wang, Z.F. Yu, H.Y. Ao, H.B. Zhang, L. Qin, O. Guillaume, D. Eglin, R.G. Richards and T.T. Tang. Anti-infective efficacy, cytocompatibility and biocompatibility of a 3D-printed osteoconductive composite scaffold functionalized with quaternized chitosan, Acta Biomaterialia, 2016, 46:112-128.（IF:6.319）
(27) H.B. Zhang, L. Zhou, and W.J. Zhang*. Control of Scaffold Degradation in Tissue Engineering: A Review. Tissue Engineering Part B, 2014, 10(5), 492-502.（IF:6.512）
(28) J. Xu, Y. Xie, H.B. Zhang*, Z. Ye*, W.J. Zhang. Fabrication of PLGA/MWNTs composite electrospun fibrous scaffolds for improved myogenic differentiation of C2C12 cells. Colloids and Surfaces B: Biointerfaces, 2014, 123, 907-915.（IF:3.977）
(29) B. Zhang, M.A.J. Moser, E.M. Zhang, Y. Luo, H.B. Zhang, W.J. Zhang. Study of the relationship between the target tissue necrosis volume and the target tissue size in liver tumours using two-compartment finite element RFA modelling. International Journal of Hyperthermia, 2014; 30(8): 593-602. （IF:3.262）
(30)H.B. Zhang, Y.Y. Yan, Y.Q. Zu. Numerical modelling of EHD effects on heat transfer and bubble shapes of nucleate boiling. Applied Mathematical Modeling, 2010, 34: 626-638.（IF:2.68）
(31) J. Wei, J.F. Jia, F. Wu, S.C. Wei, H. Zhou, H.B. Zhang. Hierarchically microporous /macroporous scaffold of magnesium–calcium phosphate for bone tissue regeneration. Biomaterials, 2010, 31, 1260–1269. (IF:8.4604)
(32) Z. Ahmad, H.B. Zhang, U. Farook, M. Edirisinghe, E. Stride, P. Colombo. Generation of multilayered structures for biomedical applications using a novel tri-needle coaxial device and electrohydrodynamic flow.Journal of the Royal Society Interface, 2008, 5(27), 1255-1261.（IF: 3.574）
(33) U. Farook, H.B. Zhang, M. Edirisinghe, E. Stride, N. Saffari. Preparation of microbubble suspensions by co-axial electrohydrodynamic atomization. Medical Engineering Physics. 2007, 29(7): 749-754. (IF:1.819）
(34) H.B. Zhang and M.J. Edirisinghe. Electrospinning of Zirconia fibers from a suspension, Journal of American Ceramic Society. 2006, 89 (6): p1870-1875.（IF:2.956）
(35) H.B. Zhang, S.N. Jayasinghe and M.J. Edirisinghe. Electrically forced microthreading of highly viscous dielectric liquids, Journal of Electrostatics, 2006, 64, p355-360.（IF:1.135）
(36) H.B. Zhang, M.J. Edirisinghe and S.N. Jayasinghe. Flow behaviour of dielectric liquids in an electric field, Journal of Fluid Mechanics, 2006, 558: p103-111.（IF:2.821）
(37) Q.Z. Chen, A.R. Boccaccini, H.B. Zhang, D.Z. Wang and M.J. Edirisinghe. Improved mechanical reliability of bone tissue engineering Scaffolds (zirconia) by electrospraying, Journal of American Ceramic Society, 2006, 89 (5): 1534-1539.（IF:2.841）